Metabolic & Weight
Metabolic & Weight Management
This group supports metabolic health and medically supervised weight management. These treatments work with your body's own appetite and blood-sugar regulation and are always used under close physician guidance.
In this category: GLP-1 Support · Dual-Receptor Support · Triple-Receptor Support · Carglinitide
GLP-1 Support
Semaglutide
GLP-1 support uses semaglutide, which works with the body's own appetite and blood-sugar regulation. It's used within medically supervised weight and metabolic programs.
How it works
Semaglutide mimics a natural gut hormone (GLP-1) that helps regulate appetite and blood sugar — supporting a feeling of fullness, reducing hunger, and helping steady blood-sugar responses.
Support for appetite regulation and reduced hunger
Support for steadier blood-sugar responses
A tool within a supervised metabolic or weight-management plan
Often paired with improvements in metabolic markers under medical guidance
Potential Benefits
Who it may suit
People pursuing weight management under medical supervision
Those working on metabolic health with a physician
Common Focus Areas
Medically supervised weight management
Metabolic health and insulin-sensitivity support
Tolerability
Mild, temporary digestive adjustment (such as nausea) can occur early and typically eases over time. Your physician monitors and adjusts your plan.
How it’s used
A once-weekly subcutaneous injection, started low and adjusted gradually by your physician. Always physician-supervised.
Dual-Receptor Support
Tirzepatide
Dual-receptor support uses tirzepatide, which works on two of the body's metabolic pathways at once. It's used within physician-supervised metabolic and weight-management programs.
How it works
Tirzepatide engages two hormone receptors involved in appetite and blood-sugar control, for a complementary effect on hunger, fullness, and metabolic regulation.
Support for appetite regulation via two pathways
Support for metabolic and body-composition goals under supervision
Support for steadier blood-sugar responses
Potential Benefits
Who it may suit
People pursuing supervised weight or metabolic goals
Those who want a dual-pathway option under medical guidance
Common Focus Areas
Medically supervised weight and metabolic management
Body-composition goals under physician guidance
Tolerability
Considered very well tolerated, with mild temporary injection-site reactions most commonly noted.
How it’s used
A once-weekly subcutaneous injection, titrated gradually under physician supervision.
Triple-Receptor Support
Retatrutide (investigational)
Triple-receptor support uses retatrutide, a newer compound that acts on three metabolic pathways. It is still investigational and used only under close physician supervision.
How it works
Retatrutide engages three pathways involved in appetite, energy use, and fat metabolism — the broadest mechanism in this class.
Support for appetite and metabolic regulation across three pathways
Explored for advanced, physician-guided metabolic goals
Potential Benefits
Who it may suit
People working on advanced metabolic goals under close medical supervision
Common Focus Areas
Advanced, closely supervised metabolic and weight management
Tolerability
As with others in this class, mild digestive adjustment can occur during titration. Because it's newer, close physician monitoring is especially important.
How it’s used
A once-weekly subcutaneous injection, titrated carefully under close physician supervision. Note: this compound is still investigational.
Cagrilintide
Amylin Analogue — optional add-on (investigational)
Cagrilintide is a long-acting analogue of amylin, a hormone the body releases alongside insulin that contributes to feelings of fullness. At Tides it is considered only as an optional addition alongside an existing GLP-1 based plan — not as a starting point on its own. It is investigational and used only under close physician supervision.
How it works
Cagrilintide works through the body's amylin pathway, which is separate from the GLP-1 pathway. It supports feelings of fullness and slows how quickly the stomach empties. Because it acts through a different mechanism, it can complement a GLP-1 plan rather than duplicate what it already does.
Additional appetite support alongside an existing GLP-1 plan
Works through a different pathway than GLP-1 treatments
May be considered when progress has plateaued
Supports feelings of fullness between meals
Potential Benefits
Who it may suit
People already on a physician-supervised GLP-1 plan
Those whose progress has stalled despite a consistent plan
Those who find appetite still difficult to manage on a GLP-1 alone
Considered as an addition, not a first step
Common Focus Areas
Plateau support under supervision
Optional add-on to a GLP-1 plan
Appetite support
Tolerability
As with others in this class, mild digestive adjustment can occur when it's introduced and typically eases with time. Because it is investigational and used as an add-on, your physician will monitor closely and adjust the overall plan as needed.
How it’s used
A once-weekly subcutaneous injection, added alongside an existing GLP-1 plan only where your physician judges it appropriate. Introduced gradually and closely supervised. Note: this compound is still investigational.
This page is for general educational information only and is not medical advice. Treatments are provided only where clinically appropriate, determined individually after a consultation with a licensed physician.